UK scientists studying the genetics of obesity in children found that FTO, a known obesity gene, also had an effect via the regulation of appetite,11-08-2008

whereby children who had two copies of the higher risk variant did not experience sensations of fullness after eating, and this probably led them to overeat.
The study is the work of researchers at University College London (UCL) and the Institute of Psychiatry, King's College London, and is published in the Journal of Clinical Endocrinology & Metabolism.
Variants of the FTO gene have been linked to obesity before, and in Caucasian populations it is the most commonly studied obesity gene, where findings have estimated that on average, adults with two copies of the variant are 3 kg (6.6 lbs) heavier, and adults with a single copy are 1.5 kg (3.3 lbs) heavier.
But in this study, Professor Jane Wardle, from UCL's department of Epidemiology & Public Health, and colleagues, wanted to discover whether the gene affected obesity via consumption or use of energy.
Read the full story at:- http://www.medicalnewstoday.com/articles/116378.php
Source: - www.medicalnewstoday.com